Related Experiment Video
Updated: Apr 18, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
7.3K
Unraveling Psoriasis Flare-up and Dengue Infection
Bárbara Agustina Hernández1, Paula Carolina Luna2, Cristina Echeverria3
1Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Journal of Psoriasis and Psoriatic Arthritis
|June 2, 2025
Summary
Dengue infection can trigger psoriasis flare-ups, with plaque psoriasis being most common. Psoriasis treatments, including biologics and methotrexate, appear safe and do not worsen dengue severity.
Area of Science:
- Dermatology and Infectious Diseases
- Clinical Research
Background:
- Dengue infection is a growing global health issue.
- Understanding its impact on patients with psoriasis is crucial for managing flare-ups and treatment efficacy.
Purpose of the Study:
- To investigate the effects of dengue infection on psoriasis exacerbations.
- To determine if psoriasis treatments influence dengue severity.
Main Methods:
- A cross-sectional descriptive study.
- Systematic collection of demographic, clinical, and treatment data from 52 patients with psoriasis experiencing flare-ups.
Main Results:
- Dengue infection triggered psoriasis flare-ups in 52 patients, most commonly plaque psoriasis (63.5%).
- Moderate dengue was most frequent (63.5%). Patients on biologic treatments (19) or methotrexate (7) did not experience severe dengue.
- Psoriasis flare-ups varied, including plaque psoriasis, guttate psoriasis, and erythroderma.
Conclusions:
- Dengue infection can precipitate psoriasis flare-ups.
- Systemic psoriasis therapies (biologics, methotrexate) appear safe and do not increase dengue severity.
- Further research is needed to understand the interplay between psoriasis severity and dengue outcomes.
Related Concept Videos
01:23Skin Diseases and Disorders
6.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.3K
01:29Autoimmune Disorders
2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.3K
01:25Inflammatory Bowel Disease III: Crohn's Disease
2
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
2
01:19Psychoneuroimmunology: Diabetes and Cancer
653
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
653
01:24T Cell Types and Functions
3.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.5K
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
1
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
1