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Related Concept Videos

Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

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Related Experiment Video

Updated: Jul 7, 2026

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
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Body-temperature responsive hydrogel adhesive for active wound closure.

Xiaowei Liu1,2,3, Haojie Yu1,4, Li Wang1,4

  • 1State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, P. R. China. hjyu@zju.edu.cn.

Journal of Materials Chemistry. B
|June 2, 2025
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This study introduces a novel temperature-responsive hydrogel tape (TRAT) for sutureless wound closure. TRAT promotes faster healing by enabling controlled wound contraction and adheres strongly to wet surfaces, showing potential for esophageal stents.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Medical Devices

Background:

  • Traditional wound closure methods can lead to prolonged healing times.
  • Cell migration-driven wound contraction is a slow natural healing process.
  • Sutureless closure requires advanced materials with specific functionalities.

Purpose of the Study:

  • To develop an innovative body-temperature responsive hydrogel tape (TRAT) for enhanced wound closure.
  • To create a hydrogel with both shape memory and robust wet surface adhesion.
  • To explore TRAT's application in esophageal stenting and anti-migration devices.

Main Methods:

  • Fabrication of a two-layer hydrogel composite: a shape memory layer (P(PTHF-co-PEG-co-PETMP)) and an adhesive layer (silk fibroin/poly(acrylic acid) network).
  • Characterization of TRAT's temperature-responsive shape memory properties.
  • Assessment of TRAT's wet surface adhesion capabilities (measured at ~150 kPa).

Main Results:

  • The developed TRAT exhibits excellent body-temperature responsive shape memory characteristics.
  • TRAT demonstrates robust adhesion to wet surfaces, crucial for internal tissue application.
  • The hydrogel tape can achieve controlled wound contraction upon temperature stimulation.
  • TRAT spontaneously unfolds and adheres to internal esophageal surfaces when temperature increases.

Conclusions:

  • TRAT offers a promising solution for sutureless wound closure and healing.
  • Its unique combination of temperature-responsiveness and wet adhesion facilitates wound contraction.
  • TRAT shows significant potential for applications like anti-migration tracheal stents.