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Beyond Traditional Silos: An Integrated Framework Leveraging Novel Pathways for Reducing Cardio-renal Risk in Type 2

Hani M Sabbour1, Mohamad Hassanein2,3, Mohamed Farghaly4

  • 1Department of Cardiology, Mediclinic Hospital, Abu Dhabi, UAE.

Current Diabetes Reviews
|June 2, 2025
PubMed

Insights

Diabetes and chronic kidney disease (CKD) significantly increase cardiovascular disease risk. Experts identified treatment gaps for managing these interconnected conditions in the Middle East.

Area of Science:

  • Cardiology
  • Nephrology
  • Diabetology

Background:

  • Diabetes mellitus is a primary driver of chronic kidney disease (CKD) progression, increasing end-stage renal disease risk.
  • CKD patients face heightened cardiovascular disease (CVD) risks, including coronary artery disease, heart failure, and arrhythmias, due to the cardiorenal connection.

Purpose of the Study:

  • To review the epidemiology, pathophysiology, diagnosis, and treatment of CKD in diabetic patients.
  • To identify treatment gaps and unmet needs for managing the cardiorenal connection in the Middle East.
  • To discuss the roles of clinical specialties in simplifying patient journeys.

Main Methods:

  • An online expert panel of cardiologists, nephrologists, and diabetologists convened in November 2021.
  • A comprehensive review of current literature on diabetes, CKD, and CVD was conducted.
  • Discussion focused on treatment options to reduce morbidity and mortality in high-risk populations.

Main Results:

  • Diabetes significantly accelerates kidney function decline and is linked to increased CVD risk.
  • The cardiorenal connection exacerbates complications in patients with diabetes and CKD.
  • Identified treatment gaps require multidisciplinary approaches for optimal patient care.

Conclusions:

  • Integrated management strategies are crucial for patients with diabetes, CKD, and CVD.
  • Simplifying the patient journey through coordinated care can improve outcomes.
  • Addressing unmet needs in the Middle East requires a focus on the cardiorenal nexus.

Keywords:
Chronic kidney diseasecardiovascular diseasediabetes mellitusfinerenonemineralocorticoid receptor antagonistrenin-angiotensin systemsodium-glucose co-transporter-2 inhibitors

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