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Updated: Sep 19, 2025

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
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Virus attacks fish by muscling its way into cells

Ping-Ping Liu1, Zhe Wei1, Xian-Wei Wang1,2

  • 1School of Life Sciences, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.

Elife
|June 2, 2025
PubMed

Insights

Nervous necrosis virus, a pathogen affecting aquatic animals, commonly enters cells through endocytosis. This study reveals it can also utilize macropinocytosis for cellular entry.

Area of Science:

  • Virology
  • Cell Biology
  • Infectious Diseases

Background:

  • Nervous necrosis virus (NNV) is a significant pathogen impacting various aquatic species.
  • Understanding NNV's cellular entry mechanisms is crucial for developing effective disease control strategies.

Discussion:

  • This research investigates alternative pathways for NNV cellular internalization.
  • The study highlights macropinocytosis as a viable route for NNV entry, in addition to the well-established endocytosis pathway.

Key Insights:

  • NNV can efficiently enter host cells via macropinocytosis.
  • This finding expands our knowledge of viral entry mechanisms and host-pathogen interactions.

Outlook:

  • Further research can explore the specific molecular players involved in NNV macropinocytosis.
  • This knowledge may lead to novel therapeutic targets for NNV infections in aquaculture.
Keywords:
cell biologyinfectious diseasemacropinocytosismicrobiologymyosin light chain 3nervous necrosis virusreceptorviruses

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