Related Experiment Video
Updated: Sep 19, 2025
11:18
Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
Published on: March 15, 2012
44.0K
Virus attacks fish by muscling its way into cells
Ping-Ping Liu1, Zhe Wei1, Xian-Wei Wang1,2
1School of Life Sciences, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Elife
|June 2, 2025
Summary
Nervous necrosis virus, a pathogen affecting aquatic animals, commonly enters cells through endocytosis. This study reveals it can also utilize macropinocytosis for cellular entry.
Area of Science:
- Virology
- Cell Biology
- Infectious Diseases
Background:
- Nervous necrosis virus (NNV) is a significant pathogen impacting various aquatic species.
- Understanding NNV's cellular entry mechanisms is crucial for developing effective disease control strategies.
Discussion:
- This research investigates alternative pathways for NNV cellular internalization.
- The study highlights macropinocytosis as a viable route for NNV entry, in addition to the well-established endocytosis pathway.
Key Insights:
- NNV can efficiently enter host cells via macropinocytosis.
- This finding expands our knowledge of viral entry mechanisms and host-pathogen interactions.
Outlook:
- Further research can explore the specific molecular players involved in NNV macropinocytosis.
- This knowledge may lead to novel therapeutic targets for NNV infections in aquaculture.
Keywords:
cell biologyinfectious diseasemacropinocytosismicrobiologymyosin light chain 3nervous necrosis virusreceptorvirusesMore Related Videos
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