Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Myocarditis IV: Nursing Management

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Triage of Individuals With Warning Symptoms of Imminent Cardiac Arrest.

Circulation. Arrhythmia and electrophysiology·2026

Same author

Lung Cancer Screening Centralization Is Associated With Improved Screening Uptake: The Veterans Healthcare Administration's Experience 2015-2021.

Chest·2026

Same author

Exploring Ambient Artificial Intelligence to Enhance Learning and Feedback During Operating Room-to-Intensive Care Unit Handoffs: Co-Design and Simulation Study.

JMIR medical education·2026

Same author

Evaluating datopotamab deruxtecan (Dato-DXd) as a novel treatment option for EGFR-mutated non-small cell lung cancer.

Future oncology (London, England)·2026

Same author

Centralization of Lung Cancer Screening and Adherence to First Follow-up Assessment: The Veterans Health Administration Experience.

Annals of the American Thoracic Society·2026

Same author

Estimating Lung Cancer Screening Eligibility in the Veterans Health Administration Using Patient-Reported Smoking Histories.

Journal of general internal medicine·2026

Search research articles

Related Experiment Video

Updated: Sep 19, 2025

Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay

Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay

Published on: September 13, 2024

Adequacy of Immune Checkpoint Inhibitor-Associated Thyroid Function Monitoring After Therapy.

Maria A Velez¹, Elliot S Kang¹, Chester A Thompson¹

¹Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA.

JCO Oncology Practice

|June 2, 2025

Summary

Post-immune checkpoint inhibitor (ICI) thyroid dysfunction is common, affecting 11.6% of monitored patients. Inadequate surveillance may lead to under-recognition of this endocrine adverse event after cancer therapy.

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Published on: February 5, 2020

Related Experiment Videos

Last Updated: Sep 19, 2025

Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay

Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay

Published on: September 13, 2024

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Published on: February 5, 2020

Area of Science:

Endocrinology
Oncology
Immunology

Background:

Immune checkpoint inhibitors (ICIs) are widely used cancer therapies.
Thyroid dysfunction is a known endocrine side effect of ICIs.
Limited data exist on thyroid dysfunction occurring after ICI treatment cessation.

Purpose of the Study:

To investigate the incidence and recognition of thyroid dysfunction after ICI therapy.
To determine if post-ICI thyroid dysfunction is under-recognized due to insufficient monitoring.

Main Methods:

Retrospective analysis of 3,626 patients treated with ICIs.
Evaluation of clinically significant thyroid dysfunction before, during, and after ICI therapy.
Assessment of thyroid laboratory surveillance rates post-treatment.

Main Results:

Clinically acted-upon thyroid dysfunction occurred in 8.1% during and 4.4% after ICI therapy.
Among patients without prior dysfunction, 11.6% developed post-ICI thyroid dysfunction.
48.6% of patients lacked post-ICI thyroid lab results; 30% with abnormal pre-discontinuation TSH developed dysfunction.

Conclusions:

Post-ICI thyroid dysfunction is frequent and potentially under-recognized.
Patients with abnormal TSH before discontinuation and those on therapy for ≤9 months warrant closer surveillance.
Enhanced post-treatment monitoring is crucial for managing ICI-induced endocrine adverse events.