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Dynamic Kinetic Asymmetric P-C Coupling of Secondary Phosphine Oxides with Alkenyl Iodides
Si-Mu Ren1, Wen-Jun Yang1, Kang Ding1
1State Key Laboratory of Medical Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300071, P. R. China.
Abstract:
Transition metal-catalyzed enantioselective P-C bond-forming reactions between racemic secondary phosphine oxides (SPOs) and various electrophiles have emerged as powerful strategies for accessing P-chiral compounds. However, most reported transformations proceeded via kinetic resolution of SPOs, inherently limiting efficiency. In contrast, dynamic kinetic asymmetric coupling enables full conversion of racemic SPOs─offering a more effective pathway─yet such methods remain rare. Herein, we report the first dynamic kinetic asymmetric P-C coupling of SPOs with alkenyl iodides. This transformation, enabled by a copper catalyst bearing a novel chiral 1,2-diamine ligand, affords a broad range of P-chiral tertiary phosphine oxides in good yields and with high enantioselectivity.
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