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Published on: March 28, 2025
Ascending aortic aneurysm and dissection risk: focus on aortic height index
Susanna Grego1, Alberto Pozzoli2, Tiziano Torre2
1Rare Cardiovascular Disease Unit, Cardiocentro Ticino Institute, EOC, Lugano, Switzerland.
Insights
The aortic diameter to height index (AHI) identifies moderate risk in acute aortic dissection patients. Patients with AHI over 2.9 cm/m require specialized assessment, regardless of absolute aortic size.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Vascular Surgery
Background:
- Acute aortic dissection (AAD) often occurs with ascending aorta dilation below surgical thresholds.
- The aortic diameter to height index (AHI) is a proposed tool for risk stratification in AAD.
- Accurate risk assessment is crucial for timely prophylactic surgery in patients with aortic dilation.
Purpose of the Study:
- To evaluate the utility of AHI in risk stratification for patients with AAD.
- To determine if AHI can improve the identification of patients requiring intervention.
- To compare AHI in AAD patients versus a control group without aortic pathology.
Main Methods:
- Retrospective analysis of prospectively collected data from 210 AAD patients operated on between 2001 and 2023.
- Calculation of AHI for all AAD patients and a control group (n=6343).
- Risk modeling analysis and simulation of the dissecting process based on AHI.
Main Results:
- 80% of AAD patients had post-junctional aortic dilation; 25% had aortic diameter > 5.5 cm.
- AHI categorized patients into low (9%), moderate (67.6%), high (21.3%), and severe (2%) risk.
- Peak AHI for dissection was 2.93 cm/m (males) and 3.05 cm/m (females). Control group AHI was 2.01 cm/m.
- Simulations indicated 3.3% of patients had AHI ≥ 2.9 cm/m.
Conclusions:
- AHI revealed a significant prevalence of moderate risk in AAD patients.
- Patients with AHI exceeding 2.9 cm/m warrant referral to an aortic center for risk assessment.
- AHI provides valuable risk stratification for acute aortic dissection, independent of absolute aortic diameter.
Objectives:
Acute aortic dissection (AAD) commonly occurs with a dilation of the ascending aorta at diameters under the threshold of surgical indication. Aortic diameter/height index (AHI) has been proposed for risk stratification and more accurate prophylactic surgery.
Methods:
From January 2001 to November 2023, all patients operated on for AAD at our Institute were prospectively collected and retrospectively analysed, calculating the AHI. A Control Group without aortic pathology was stratified for the same risk index, and a modelling risk analysis for aortic dissection was also performed.
Results:
A group of 210 patients was operated during the study period, of whom 168 (80%) had a prevalent post-junctional aortic dilation with a mean aortic diameter at the time of diagnosis of 5.1 ± 0.7 cm. In 53/210 (25%), the aortic diameter was > 5.5 cm. According to AHI, 19/210 patients (9%) were low-risk, 142/210 (67.6%) moderate, 45/210 (21.3%) high and 4/210 (2%) severe risk. In the AHI probability density function, the peak for dissection was 2.93 cm/m for males and 3.05 for females. Control were 6343 patients (3.2% at moderate risk) with AHI of 2.01 cm/m. After simulating the dissecting process, 215 (3.3%) had AHI ≥ 2.9 cm/m.
Conclusions:
The measurement of the aortic diameter to height index in patients with acute aortic dissection revealed a significant prevalence of individuals presenting a moderate risk for acute aortic events. Regardless of absolute aortic diameter values, patients with AHI exceeding 2.9 cm/m should be referred to an aortic centre for multidisciplinary risk assessment.
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