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Related Experiment Video

Updated: Sep 19, 2025

Measuring Local Anaphylaxis in Mice
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Tranexamic acid-induced anaphylaxis: a systematic review.

Pei-Shuang Lin1,2, Yun-Tai Yao3,4,5,6, Alparslan Turan7,8

  • 1Department of Cardiovascular Surgery, Fujian Medical University Affiliated First Quanzhou Hospital, Fujian, 362000, China.

European Journal of Clinical Pharmacology
|June 2, 2025
PubMed
Summary
This summary is machine-generated.

Anaphylaxis to tranexamic acid (TXA) is rare but serious. This review of 15 cases highlights common symptoms like hypotension and rash, emphasizing prompt recognition and treatment for optimal outcomes.

Keywords:
Adverse reactionAllergyAnaphylaxisSkin testTranexamic acid

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Area of Science:

  • Pharmacology
  • Allergy and Immunology

Background:

  • Tranexamic acid (TXA) is a widely used antifibrinolytic agent for hemorrhage control.
  • Despite a generally favorable safety profile, rare cases of anaphylaxis have been reported.

Approach:

  • A systematic literature review was conducted using PubMed, Embase, and Web of Science.
  • Case reports of anaphylactic reactions to TXA were identified and analyzed for clinical characteristics, diagnosis, and treatment.

Key Points:

  • Fifteen cases of TXA-induced anaphylaxis were identified, affecting patients aged 2 to 80 years.
  • Common symptoms included hypotension, hypoxia, and rash (66.7%), followed by tachycardia (60.0%).
  • Allergological workup confirmed TXA as the allergen in 73.3% of cases; treatment involved corticosteroids, epinephrine, and antihistamines.

Conclusions:

  • Anaphylaxis to TXA is a rare adverse drug reaction with diverse clinical presentations.
  • Early identification and appropriate management are crucial for favorable patient outcomes.