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Acute interstitial nephritis associated with ondansetron
Olga Charnaya1, Elizabeth Goswami2
1Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ocharna1@jhmi.edu.
Pediatric Nephrology (Berlin, Germany)
|June 2, 2025
Summary
A 16-year-old experienced acute kidney injury after ondansetron use. Kidney function improved after medication withdrawal, highlighting ondansetron
Area of Science:
- Nephrology
- Clinical Pharmacology
Background:
- Acute kidney injury (AKI) can present with diverse etiologies.
- Medication-induced nephrotoxicity is a significant concern in adolescent health.
Purpose of the Study:
- To report a case of severe kidney dysfunction potentially linked to ondansetron in a 16-year-old male.
- To investigate the association between ondansetron exposure and acute kidney injury.
Main Methods:
- Case report of a 16-year-old male with seizure and severe kidney dysfunction.
- Clinical observation of kidney function following medication review and withdrawal.
- Analysis of patient's exposure history, including ondansetron and ibuprofen.
Main Results:
- The patient presented with severe kidney dysfunction and dilute urine.
- Kidney function significantly improved after discontinuation of all prior medications, including ondansetron.
- Recurrence of kidney dysfunction after a subsequent dose of ondansetron, with normalization upon withdrawal.
Conclusions:
- Ondansetron may be associated with acute kidney injury in adolescents.
- Prompt recognition and withdrawal of the offending agent are crucial for kidney function recovery.
- Further investigation into ondansetron's nephrotoxic potential is warranted.
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