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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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LSINCT5: a pivotal oncogenic long non-coding RNA in cancers
Sharanya K Sritharan1, Amar Harris Arifin2, Shamala Salvamani3
1Division of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.
Functional & Integrative Genomics
|June 2, 2025
Summary
Long stress-induced non-coding transcript 5 (LSINCT5), a long non-coding RNA (lncRNA), promotes cancer progression by affecting cell activity and signaling pathways. Its overexpression suggests potential as a cancer biomarker and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long stress-induced non-coding transcript 5 (LSINCT5) is a long non-coding RNA (lncRNA) frequently overexpressed in various cancers.
- Upregulation of LSINCT5 is linked to malignant clinicopathological features and promotes cancer progression.
Purpose of the Study:
- To review the biological functions, expression patterns, oncogenic roles, and molecular mechanisms of LSINCT5 in cancer.
- To highlight LSINCT5's potential as a diagnostic/prognostic biomarker and therapeutic target.
Main Methods:
- Literature review of studies on LSINCT5 in cancer.
- Analysis of molecular mechanisms including miRNA sponging, protein interactions, and transcription factor regulation.
Main Results:
- LSINCT5 overexpression drives proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT).
- LSINCT5 influences cancer progression by regulating gene expression and interfering with signaling pathways.
Conclusions:
- LSINCT5 exhibits significant oncogenic properties in various cancers.
- Understanding LSINCT5's complex roles is crucial for its therapeutic application.
- LSINCT5 holds promise as a valuable biomarker and therapeutic target for cancer treatment.
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