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Updated: Jun 14, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Copper-Catalyzed Stereoconvergent 1,4-Protosilylation of E/Z Dienes
Longtao Huang1,2, Yueyuan Wang2, Min Gao3
1Central Hospital of Dalian University of Technology, Dalian, Liaoning 116024, China.
Abstract:
The conversion of E/Z isomeric olefin mixtures to a singular product is both significant and challenging. In this study, we present a copper-catalyzed stereoconvergent 1,4-protosilylation of E/Z conjugated diene mixtures, yielding allylic silanes with exclusive 1,4-regioselectivity and a Z configuration. Density functional theory (DFT) calculations indicate stereoconvergent 1,4-protosilylation through Zimmerman-Traxler transition states during the protonation step, leading to the formation of the final Z isomer, allylic silane.
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