Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Cell Death

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...

Autophagic Cell Death

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

uPAR-Guided Dendrimer Gel Nanoparticles Reprogram Inflammation to Stabilize Atherosclerotic Plaques.

ACS applied materials & interfaces·2026

Same author

Co-Transfected Plasmids Enhance Transient Expression of Reporter Genes.

Biotech (Basel (Switzerland))·2026

Same author

Predictive monitoring, identification, and control of Microcystis blooms in a drinking water source basin: An integrative artificial intelligence and bioinformatics approach.

Journal of hazardous materials·2026

Same author

Predictive surveillance and diagnosis of COVID-19: An integrative machine learning and wastewater multi-omics approach.

Water research·2025

Same author

Dendrimer Gel Nanoparticles with Dual-Targeting of uPAR and Ribonucleotide Reductase R2 Influence Necrosis, Apoptosis, and Cell Cycle Arrest in Triple-Negative Breast Cancer.

Molecular pharmaceutics·2025

Same author

Evaluating the Toxicity of Electronic Cigarette Aerosols for Firsthand and Secondhand Exposure Under Different Device Operating Conditions.

Chemical research in toxicology·2025

Search research articles

Related Experiment Video

Updated: Apr 10, 2026

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Published on: May 16, 2025

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria.

Meng-Jiun Lai¹, Jonathan Wijaya², Yue-Wern Huang³

¹Department of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University.

Journal of Visualized Experiments : Jove

|June 2, 2025

Summary

This summary is machine-generated.

Copper nanoparticles (CuNPs) show promise in combating drug-resistant bacteria like E. coli and S. aureus. This research explores CuNP mechanisms and suggests potential bacterial resistance development, offering new strategies against infections.

More Related Videos

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

Production of Metal Nanoparticles by Pulsed Laser-ablation in Liquids: A Tool for Studying the Antibacterial Properties of Nanoparticles

Production of Metal Nanoparticles by Pulsed Laser-ablation in Liquids: A Tool for Studying the Antibacterial Properties of Nanoparticles

Published on: June 2, 2017

Related Experiment Videos

Last Updated: Apr 10, 2026

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Published on: May 16, 2025

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

Production of Metal Nanoparticles by Pulsed Laser-ablation in Liquids: A Tool for Studying the Antibacterial Properties of Nanoparticles

Production of Metal Nanoparticles by Pulsed Laser-ablation in Liquids: A Tool for Studying the Antibacterial Properties of Nanoparticles

Published on: June 2, 2017

Area of Science:

Biomedical Engineering
Nanotechnology
Antimicrobial Research

Background:

Antibiotic resistance is a growing global health threat.
Nanomaterials offer novel antimicrobial strategies.
Copper nanoparticles (CuNPs) are investigated for bactericidal properties.

Purpose of the Study:

To evaluate CuNPs as bactericides against multidrug-resistant pathogens.
To elucidate the antimicrobial mechanisms of CuNPs.
To explore bacterial programmed cell death pathways and potential copper resistance.

Main Methods:

Synthesis of 20 nm and 60 nm CuNPs.
Bactericidal efficacy assessed via colony assays.
Mechanisms studied through reactive oxygen species (ROS) analysis and programmed cell death (PCD) pathway modulators.

Main Results:

CuNPs demonstrated bactericidal activity against E. coli, A. baumannii, and S. aureus.
ROS production was identified as a key antimicrobial mechanism.
Evidence suggests potential for bacterial copper resistance development.

Conclusions:

CuNPs present a viable alternative to antibiotics for combating resistant bacteria.
Understanding CuNP mechanisms and resistance is crucial for therapeutic development.
This study provides a framework for evaluating nanoparticle antimicrobial potential.