A Dual-Factor Scaffold for Spinal Cord Injury Repair Targeting Inflammation and Ferroptosis

Spinal cord injury (SCI) is a condition with severe consequences, and its treatment poses significant challenges. The local inflammatory microenvironment and neuronal death following SCI are primary factors contributing to recovery difficulties. In this study, we combined exosomes that inhibit the inflammatory response with deferoxamine, a compound that chelates excessive iron ions and mitigates ferroptosis, using methacrylated chitosan as a scaffold. These two factors were integrated through two distinct methods: ionic interaction and covalent binding, allowing for the sustained release of both components. Our in vivo and in vitro results indicate that this hydrogel scaffold can enhance the inflammatory microenvironment post injury and diminish neuronal death by inhibiting ferroptosis. Consequently, it can facilitate tissue and functional recovery after SCI, presenting a novel and viable strategy for SCI repair.