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Curcumin in Type 2 Diabetes Mellitus: A Natural Approach to Modulating Metabolic Dysfunction
Rufaida Wasim1, Sumaiya Azmi2, Mohammad Owais1
1Faculty of Pharmacy, Integral University, Lucknow (UP) India.
Drug Research
|June 2, 2025
Summary
Curcumin, a compound from turmeric, shows promise in managing type 2 diabetes mellitus (T2DM). Its anti-inflammatory and antioxidant properties help control blood sugar and improve insulin resistance, suggesting potential as a natural T2DM treatment.
Area of Science:
- Pharmacology
- Metabolic Diseases
- Natural Products
Background:
- Type 2 diabetes mellitus (T2DM) is a growing global health issue.
- Bioactive compounds from herbal medicine offer therapeutic benefits for T2DM.
- Curcumin, from turmeric (Curcuma longa), is gaining attention for its health effects.
Purpose of the Study:
- To summarize the antidiabetic actions and mechanisms of curcumin.
- To review preclinical and clinical evidence supporting curcumin's role in T2DM prevention and management.
Main Methods:
- Review of in vitro and in vivo studies on curcumin's pharmacological effects.
- Analysis of preclinical research and clinical trials on curcumin's antidiabetic properties.
Main Results:
- Curcumin exhibits antioxidant, anti-inflammatory, hypoglycemic, and insulin-sensitizing effects.
- Animal models show curcumin improves -cell function and reduces insulin resistance.
- Evidence suggests curcumin's efficacy through multiple pathways, including anti-inflammatory and antioxidant actions.
Conclusions:
- Curcumin demonstrates significant potential for the prevention and management of T2DM.
- Its multifaceted properties, including anti-inflammatory, antioxidant, antihyperglycemic, and antihyperlipidemic effects, contribute to its therapeutic success.
- Curcumin represents a promising natural therapeutic option for T2DM.
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