Non-coding RNA biomarkers in basal-like breast cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Non-coding RNAs (ncRNAs) are key regulators in basal-like breast cancer (BLBC), offering potential as biomarkers for early diagnosis and prognosis. ncRNA-based therapies show promise for improving treatment efficacy and overcoming resistance in BLBC.
Area Of Science
- Oncology
- Molecular Biology
- Genomics
Background
- Basal-like breast cancer (BLBC) is an aggressive subtype with poor outcomes and limited treatment options.
- Accurate diagnosis and prognosis stratification are critical challenges in BLBC management.
- Non-coding RNAs (ncRNAs) are increasingly recognized as vital regulators in cancer development.
Purpose Of The Study
- To review the current understanding of ncRNA roles in BLBC tumorigenesis and progression.
- To highlight the potential of ncRNAs as diagnostic and prognostic biomarkers.
- To discuss emerging ncRNA-based therapeutic strategies for BLBC.
Main Methods
- Comprehensive literature review of ncRNA functions in BLBC.
- Analysis of ncRNA expression patterns and their clinical relevance.
- Synthesis of data on ncRNA-based diagnostic and therapeutic approaches.
Main Results
- ncRNAs, including miRNAs, lncRNAs, siRNAs, and circRNAs, significantly influence BLBC pathways.
- Stable and subtype-specific ncRNA expression in body fluids suggests biomarker potential.
- ncRNA-based therapeutics offer novel strategies against BLBC and treatment resistance.
Conclusions
- ncRNAs hold significant promise as minimally invasive biomarkers for early detection, prognosis, and treatment monitoring in BLBC.
- ncRNA-based therapies represent a promising avenue for precision medicine in BLBC.
- Further research is needed to standardize assays and optimize delivery for clinical translation.
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