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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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Related Experiment Video

Updated: Sep 19, 2025

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Non-coding RNA biomarkers in basal-like breast cancer.

Haider Ali1, Nawaid Hussain Khan2, Dalila Cano3

  • 1Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 2, 2025
PubMed
Summary

Non-coding RNAs (ncRNAs) are key regulators in basal-like breast cancer (BLBC), offering potential as biomarkers for early diagnosis and prognosis. ncRNA-based therapies show promise for improving treatment efficacy and overcoming resistance in BLBC.

Keywords:
Basal-like breast cancer (BLBC)BiomarkerscircRNAslncRNAsmiRNAsncRNAssiRNAs

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Basal-like breast cancer (BLBC) is an aggressive subtype with poor outcomes and limited treatment options.
  • Accurate diagnosis and prognosis stratification are critical challenges in BLBC management.
  • Non-coding RNAs (ncRNAs) are increasingly recognized as vital regulators in cancer development.

Purpose of the Study:

  • To review the current understanding of ncRNA roles in BLBC tumorigenesis and progression.
  • To highlight the potential of ncRNAs as diagnostic and prognostic biomarkers.
  • To discuss emerging ncRNA-based therapeutic strategies for BLBC.

Main Methods:

  • Comprehensive literature review of ncRNA functions in BLBC.
  • Analysis of ncRNA expression patterns and their clinical relevance.
  • Synthesis of data on ncRNA-based diagnostic and therapeutic approaches.

Main Results:

  • ncRNAs, including miRNAs, lncRNAs, siRNAs, and circRNAs, significantly influence BLBC pathways.
  • Stable and subtype-specific ncRNA expression in body fluids suggests biomarker potential.
  • ncRNA-based therapeutics offer novel strategies against BLBC and treatment resistance.

Conclusions:

  • ncRNAs hold significant promise as minimally invasive biomarkers for early detection, prognosis, and treatment monitoring in BLBC.
  • ncRNA-based therapies represent a promising avenue for precision medicine in BLBC.
  • Further research is needed to standardize assays and optimize delivery for clinical translation.