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Published on: March 8, 2018
Draft genome sequence of Kodamaea ohmeri, an emerging human pathogen
Liping Liu1, Qiuping Wang2, Hui Wang3
1Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China; The HengDianWengRong Hospital, Dongyang 322100, China.
The draft genome of the emerging fungal pathogen Kodamaea ohmeri was sequenced, revealing key genes for pathogenicity and virulence. This provides a foundation for understanding its role in severe human infections.
Area of Science:
- Mycology
- Genomics
- Medical Microbiology
Background:
- Kodamaea ohmeri is an emerging fungal pathogen causing severe human infections.
- Lack of genome data hinders understanding of its pathogenic mechanisms.
Purpose of the Study:
- To report the draft genome sequence of Kodamaea ohmeri 3873 from clinical samples.
- To identify genes related to pathogenicity and virulence.
Main Methods:
- Genome sequencing of K. ohmeri 3873.
- Bioinformatic analysis to identify genes (e.g., carbohydrate-active enzymes, CYP genes, secondary metabolite genes, pathogenicity-related genes, virulence factors).
Main Results:
- The K. ohmeri genome is 13.86 Mb with 3734 putative genes and 54.22% repeat sequences.
- Identified 159 carbohydrate-active enzymes, 19 CYP genes, and 44 secondary metabolite genes.
- Discovered 657 pathogenicity-related genes and 216 fungal virulence factors, exceeding other strains.
Conclusions:
- The genome sequence provides a valuable resource for studying K. ohmeri biology and pathogenesis.
- The identified genes suggest a strong potential for K. ohmeri as an emerging human pathogen.
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