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Updated: Sep 19, 2025

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
ACE2/Angiotensin-(1-7)/Mas and the brain
Maria José Campagnole-Santos1, Marco Antônio Peliky Fontes1, Thiago Verano-Braga1
1Department of Physiology and Biophysics, INCT-Nanobiofar, Biological Sciences Institute, Universidade Federal de Minas Gerais, Brazil.
Abstract:
It is well known that the renin-angiotensin system (RAS) plays a key role in regulating blood pressure and hydroelectrolyte balance. In addition to angiotensin (Ang) II, Ang-(1-7) has emerged as an important component of this system. Here we review evidence regarding the presence and actions of ACE2/Ang-(1-7)/Mas receptor pathway within the central nervous system, where the RAS possesses a crucial role in controlling cardiovascular, metabolic and stress-coping behavior functions. The involvement of this non-canonical RAS pathway in the brain mechanisms related to hypertension will also be discussed.
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