ACE2/Angiotensin-(1-7)/Mas and the brain

Area of Science:

• Neuroscience
• Cardiovascular Science
• Endocrinology

Background:

• The renin-angiotensin system (RAS) regulates blood pressure and fluid balance.
• Angiotensin II (Ang II) is a key RAS component, but Angiotensin (1-7) [Ang-(1-7)] also plays a significant role.
• The central nervous system (CNS) is vital for cardiovascular, metabolic, and stress responses via the RAS.

Purpose of the Study:

• To review the evidence for the ACE2/Ang-(1-7)/Mas receptor pathway in the brain.
• To discuss the role of this pathway in CNS functions.
• To explore the involvement of this non-canonical RAS pathway in brain mechanisms of hypertension.

Main Methods:

• Literature review of studies on the ACE2/Ang-(1-7)/Mas receptor pathway in the CNS.
• Analysis of research on RAS involvement in cardiovascular, metabolic, and behavioral regulation.
• Examination of studies linking central RAS to hypertension.

Main Results:

• The ACE2/Ang-(1-7)/Mas receptor pathway is present and active within the CNS.
• This pathway influences cardiovascular control, metabolism, and stress-coping behaviors.
• Evidence suggests this pathway is implicated in the central mechanisms of hypertension.

Conclusions:

• The ACE2/Ang-(1-7)/Mas receptor pathway is a critical non-canonical component of the brain RAS.
• This pathway significantly impacts CNS functions related to blood pressure regulation and behavior.
• Targeting this pathway may offer novel therapeutic strategies for hypertension.