Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Receptors: Overview01:22

Opioid Receptors: Overview

2.0K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
2.0K
Analgesia and Pain Management01:25

Analgesia and Pain Management

823
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
823
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

382
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
382
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

2.0K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
2.0K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

454
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
454
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

816
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
816

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD).

Comprehensive Physiology·2025
Same author

Microbiota in Gut-Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease.

Comprehensive Physiology·2025
Same author

TRPV4 Channels Mediate Bladder Cancer Cell Proliferation, Migration and Chemoresistance.

bioRxiv : the preprint server for biology·2025
Same author

37th Annual Meeting of the Ohio Physiological Society: October 6-7, 2023, The University of Toledo, Toledo, Ohio.

Advances in physiology education·2024
Same author

Prostaglandin E<sub>2</sub> attenuates lung fibroblast differentiation via inactivation of yes-associated protein signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2023

Related Experiment Video

Updated: Sep 19, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K

Opioid receptors in cardiovascular function.

Venkatesh Katari1, Kesha K Dalal1, Narendra Kondapalli1

  • 1The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA.

British Journal of Pharmacology
|June 2, 2025
PubMed
Summary
This summary is machine-generated.

Opioid receptors in the heart modulate cardiac function, influencing heart rate and contractility for cardioprotection. Understanding these G protein-coupled receptors offers potential for new cardiovascular disease treatments.

Keywords:
cardioprotectioncardiovascularexcitation–contraction couplingischaemia–reperfusionopioid receptors

More Related Videos

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

28.8K
Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
10:53

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Published on: February 26, 2018

47.0K

Related Experiment Videos

Last Updated: Sep 19, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K
Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

28.8K
Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
10:53

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Published on: February 26, 2018

47.0K

Area of Science:

  • Cardiovascular Science
  • Pharmacology
  • Molecular Biology

Background:

  • Opioid receptors are G protein-coupled receptors found in cardiac myocytes and nerve fibers.
  • These receptors play a vital role in regulating cardiac function, including neural transmission, heart rate, and myocyte contractility.
  • Opioid signaling contributes to cardioprotection.

Purpose of the Study:

  • To comprehensively review the functions of opioid receptors in various cardiovascular cell types.
  • To examine the role of opioid receptors in excitation-contraction coupling and vascular tone regulation.
  • To explore the interactions between opioid receptors and other cardiovascular systems, such as the β-adrenoceptor and renin-angiotensin systems.

Main Methods:

  • Literature review of existing research on opioid receptors in the cardiovascular system.
  • Analysis of studies investigating opioid receptor signaling pathways in cardiomyocytes, endothelial cells, and smooth muscle cells.
  • Synthesis of information on the crosstalk between opioid receptors and other relevant physiological systems.

Main Results:

  • Opioid receptors significantly influence cardiovascular homeostasis through diverse cellular mechanisms.
  • These receptors modulate key cardiac functions like excitation-contraction coupling and vascular tone.
  • Interactions with systems like β-adrenoceptors and the renin-angiotensin system highlight complex regulatory networks.

Conclusions:

  • Opioid receptors and their signaling pathways are crucial mediators of cardiovascular functions.
  • A deeper understanding of these receptors provides insights into maintaining cardiovascular homeostasis.
  • Opioid receptors represent promising therapeutic targets for various cardiovascular diseases.