Related Experiment Video
Updated: Aug 14, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Studies on the absorption of sodium guaiazulene-3-sulfonate. I
Abstract:
From the view points of safety and efficacy of sodium guaiazulene-3-sulfonate (GAS) after oral cavity administration, the absorption behavior of GAS was investigated in rats and rabbits and following results were obtained. 1) GAS was absorbed not from oral cavity but from nasal cavity in rats and rabbits. 2) The in situ perfusion experiments revealed the existence of dose-dependent specific absorption mechanism in the rat small intestine. 3) GAS was absorbed from neither the rat stomach nor the rectum. These facts reveal that GAS transfers into the systemic circulation only through the small intestine after the clinical application to the oral cavity. And these absorption characteristics of GAS are suited for its direct action on the inflamed oral mucosa. When GAS is administered into the oral cavity, the safety is at least the same as that obtained after oral administration.
More Related Videos
Related Concept Videos
Glucose Absorption Into the Small Intestine
Drug Absorption: Factors Affecting GI Absorption
In...
Factors Influencing Drug Absorption: Physicochemical Parameters
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Methods for Studying Drug Absorption: In situ
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
Phase II Reactions: Glucuronidation

