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Updated: Sep 19, 2025

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Correction: Prolonged opioid use after single-level lumbar spinal fusion surgery in a Belgian population: a

Vincent Raymaekers1,2,3, Gert Roosen4,5,6,7, Eric Put4,5,6,7

  • 1Department of Neurosurgery, Antwerp University Hospital, Antwerp, Belgium. vincent.raymaekers@gmail.com.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
|June 2, 2025
PubMed
Abstract

No abstract available in PubMed .

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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