Related Experiment Video
Updated: Sep 19, 2025
How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
Published on: December 14, 2014
Can ginger improve cardiovascular health indices? A protocol for a GRADE-assessed systematic review and planned
Ali Jafari1,2, Amirhossein Sahebkar3,4,5
1Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ajafari.nut@gmail.com.
Background:
Cardiovascular diseases (CVDs), which encompass a range of disorders impacting the heart and blood vessels, continue to pose a significant global public health challenge. Ginger (Zingiber officinale) has attracted attention among various treatment options for its potential advantages in promoting cardiovascular well-being. Renowned for its anti-inflammatory, antioxidant, and anti-hypertensive properties, ginger is a widely used culinary and medicinal plant. The objective of this research is to provide a comprehensive summary and systematic analysis of the existing scientific literature pertaining to the effects of ginger supplementation on glycemic profile, lipid profile, anthropometric measures, blood pressure, inflammatory markers, liver function tests, oxidative stress parameters, and adipokines. This analysis aims to establish a foundation for clinical interventions.
Methods:
A methodical electronic exploration will be carried out to discover articles in various databases such as Scopus, PubMed, EMBASE, CENTRAL, and Web of Science. The search will specifically target randomized controlled trials (RCTs) that include both healthy and diseased individuals. Two evaluators will independently review articles, extract information, and evaluate the quality of the studies using the Cochrane risk of bias assessment tool (RoB 2). Any discrepancies will be addressed by involving a third reviewer. The quality of cumulative evidence will be evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria. Should a sufficient quantity of suitable studies be found, a meta-analysis will be conducted on the chosen outcomes.
Discussion:
This protocol outlines a comprehensive approach for systematically reviewing and conducting a dose-response meta-analysis on the effects of ginger supplementation on CVD risk factors. The proposed methodological rigor, including independent evaluation and GRADE assessment, will ensure high-quality evidence synthesis from available RCTs. The findings from this planned review will help inform future research directions and potentially guide clinical recommendations regarding ginger supplementation for cardiovascular health.
Systematic Review Registration:
PROSPERO: CRD42024571362.
More Related Videos
Related Concept Videos
01:16Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
01:26Atherosclerosis III: Management
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
01:23Assessment of the Cardiovascular System I: Subjective Data
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
01:26Coronary Artery Disease IV: Preventive Measures
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...