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Updated: Feb 28, 2026

Isolation and Characterization of Cyanobacterial Extracellular Vesicles
Published on: February 3, 2022
Translational horizons in bacterial membrane vesicles: Hotspots and frontiers from basic medicine to clinical
Jian-Xuan Sun1, Mei-Cheng Liu1, Si-Yang Ma1
1Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Abstract:
Bacterial membrane vesicles (BMVs) represent a class of nanoscale lipid particles released by both Gram-positive and Gram-negative bacteria, serving as versatile mediators of intercellular communication and host-pathogen interactions. Their unique biogenesis pathways and functional properties have positioned them as promising targets for therapeutic and biotechnological applications. To comprehensively assess the research trends of this dynamic research field, we conducted a bibliometric analysis of 6,352 studies on BMVs published between 1 January 2014 and 19 November 2024 using VOSviewer, CiteSpace, and the R package "bibliometrix." Our analysis revealed that the Chinese Academy of Sciences led institutional contributions, while Frontiers in Microbiology emerged as the most active journal. Kim, Yoon-Keun was the most prolific author, reflecting his significant influence in the field. Key research hotspots were categorized into four frontiers: biogenesis mechanisms, pathogenesis and immune regulation, clinical applications, and methodological and engineering innovations.
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