Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-reported outcomes as early indicators of recurrence, disease progression, and survival via machine learning in breast cancer.

NPJ breast cancer·2026
Same author

Enhanced gastrointestinal stability and therapeutic efficacy of biofilm self-coated Bacillus amyloliquefaciens C-1 probiotic in ulcerative colitis.

NPJ science of food·2026
Same author

MFAP4 activates PI3K/AKT-NF-κB signaling to drive tumor progression and immune evasion in bladder cancer.

International immunopharmacology·2026
Same author

A Trojan Horse in the soil: Tetracycline hijacks plant organellar ribosomes to stunt growth and unbalance the rhizosphere microecology.

Journal of hazardous materials·2026
Same author

Decoding the anti-glioma potential of saponins: structure-activity relationships, mechanism and development strategy.

European journal of medicinal chemistry·2026
Same author

A modification-free nanochannel platform for monitoring cerebral β-amyloid peptides based on the dispersion of stimuli-responsive polymer-modified gold nanoparticles.

Chemical communications (Cambridge, England)·2026

Related Experiment Video

Updated: Sep 19, 2025

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.5K

A Multifunctional Electrochemical Biosensor Based on Near-Infrared Light-Responsive Hydrogel for In Vivo Recording

Congyu Zhang1, Qi Zheng1, Cui Li1

  • 1School of Pharmacy, Nantong University, Nantong 226019, People's Republic of China.

Analytical Chemistry
|June 3, 2025
PubMed
Summary
This summary is machine-generated.

This study presents a novel near-infrared light-responsive device for neural signal monitoring and modulation. The device utilizes enzyme-loaded composites for precise control over bioelectrocatalysis and in vivo glucose monitoring, offering potential for neurodegenerative disease treatment.

More Related Videos

In Vitro Multiparametric Cellular Analysis by Micro Organic Charge-modulated Field-effect Transistor Arrays
10:05

In Vitro Multiparametric Cellular Analysis by Micro Organic Charge-modulated Field-effect Transistor Arrays

Published on: September 20, 2021

2.5K
Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

3.9K

Related Experiment Videos

Last Updated: Sep 19, 2025

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.5K
In Vitro Multiparametric Cellular Analysis by Micro Organic Charge-modulated Field-effect Transistor Arrays
10:05

In Vitro Multiparametric Cellular Analysis by Micro Organic Charge-modulated Field-effect Transistor Arrays

Published on: September 20, 2021

2.5K
Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

3.9K

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Neural signal monitoring and regulation are vital for managing neurological disorders.
  • Existing methods often lack precise spatiotemporal control and multifunctionality.
  • Developing advanced tools is crucial for diagnostics and therapeutics in neurodegenerative diseases.

Purpose of the Study:

  • To construct a near-infrared light (NIR)-responsive device for controllable neural signal recording and modulation.
  • To investigate the device's capability for in vivo glucose monitoring and its therapeutic potential in Parkinson's disease models.

Main Methods:

  • Fabrication of microelectrodes modified with enzyme-loaded microgels and multiwalled carbon nanotubes (MWCNTs).
  • Utilizing the photothermal effect of MWCNTs to convert NIR light into heat for controlled bioelectrocatalysis.
  • In vivo implantation for glucose monitoring and photothermal activation of TRPV1 channels.

Main Results:

  • The device demonstrated controllable enzyme-catalyzed reactions modulated by NIR light.
  • Accurate in vivo glucose monitoring from 0.3 to 6.0 mM with a detection limit of 0.098 mM and 2-hour stability.
  • Photothermal activation promoted microglia autophagy and alpha-synuclein degradation in a Parkinson's disease mouse model.

Conclusions:

  • The NIR-responsive device offers high spatiotemporal controllability, biocompatibility, and multifunctionality.
  • This system shows significant promise for the diagnostics and therapeutics of neurodegenerative diseases.
  • The technology enables precise modulation of neural signals and biological processes.