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Related Experiment Videos

Radionuclide esophageal transit in progressive systemic sclerosis.

S Carette, Y Lacourciere, S Lavoie

    The Journal of Rheumatology
    |June 1, 1985
    PubMed
    Summary

    Radionuclide esophageal transit (RT) is a sensitive, noninvasive test for progressive systemic sclerosis (PSS) affecting the esophagus. Abnormal RT patterns were common in PSS patients, suggesting it as a potential alternative to esophageal manometry.

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    Area of Science:

    • Gastroenterology
    • Nuclear Medicine
    • Rheumatology

    Background:

    • Progressive systemic sclerosis (PSS) frequently involves the esophagus, leading to motility disorders.
    • Esophageal dysfunction in PSS can cause significant symptoms and complications.
    • Esophageal manometry is the standard for assessing esophageal motility but can be invasive.

    Purpose of the Study:

    • To evaluate radionuclide esophageal transit (RT) as a noninvasive diagnostic tool for esophageal dysfunction in patients with PSS.
    • To compare the sensitivity and specificity of RT with esophageal manometry in PSS patients.
    • To identify characteristic RT patterns associated with esophageal involvement in PSS.

    Main Methods:

    • Twenty-three patients with PSS underwent both radionuclide esophageal transit (RT) and esophageal manometry.

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  • Esophageal transit time and radionuclide distribution were analyzed.
  • Manometric findings, including sphincter function and peristalsis, were recorded.

    • Main Results:

    • Twenty-two of 23 PSS patients (96%) had abnormal esophageal manometry.
    • Twenty of 22 patients with abnormal manometry (91%) showed abnormal RT, primarily prolonged transit time.
    • A distinct RT pattern of radionuclide stagnation in the distal and middle esophagus was observed in 82% of patients with advanced esophageal involvement.
    • Fifteen of 19 controls (79%) had normal RT; four showed prolonged transit without stagnation.

    Conclusions:

    • Radionuclide esophageal transit (RT) is a safe, highly sensitive, and noninvasive method for detecting esophageal dysfunction in PSS.
    • RT may serve as a valuable alternative to esophageal manometry for assessing esophageal involvement in PSS.
    • While sensitive, RT may lack specificity in diagnosing specific motility disorders within PSS.