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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

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Published on: December 23, 2016

Quercetin-Eudragit® polymer complexes with enhanced loading, solubility, stability, and site-specific targeting.

Siddharth S Kesharwani¹, Casey L Sayre^1,2, Sharyu Kesharwani³

¹College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT, USA.

Therapeutic Delivery

|June 3, 2025

Summary

This summary is machine-generated.

This study developed a polymer-based platform to improve quercetin delivery to the colon. The novel Quercetin-Eudragit® complexes show enhanced solubility, stability, and efficacy against colon cancer cells, overcoming bioavailability challenges.

Keywords:

Eudragit® S100 Eudragit® polymers Quercetin and formulation development colon targeting pH-dependent delivery polymer complexes site-specific delivery

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Area of Science:

Pharmacology
Materials Science
Drug Delivery

Background:

Quercetin, a natural compound, shows promise for chronic disease prevention.
Poor oral bioavailability of quercetin due to low solubility and permeability limits its therapeutic application.
Targeted delivery systems are needed to enhance quercetin's effectiveness.

Purpose of the Study:

To develop a polymer-based platform for targeted colon delivery of quercetin.
To improve quercetin's solubility, stability, and oral absorption.
To evaluate the efficacy of the developed quercetin-polymer complexes in colon cancer cells.

Main Methods:

Quercetin complexes were prepared using co-precipitation with Eudragit® S100/L100/L100-55 polymers.
Ethanol and polyvinyl alcohol were used as solvent and surfactant, respectively.
Characterization included loading capacity, solubility, stability, and in vitro cytotoxicity assays.

Main Results:

Polymer complexes exhibited high quercetin loading capacity (~315 μg/mL).
Complexes showed amorphous nature, solubility at pH > 5.5, and significantly increased aqueous solubility (> 1 mg/mL).
Enhanced stability (>30 h) and improved reduction in colon cancer cell viability (HCT116, HT29) were observed.

Conclusions:

Successful development of a polymer-quercetin complex for targeted colon delivery.
The developed complex demonstrates improved loading, solubility, stability, and enhanced anti-cancer activity.
This platform offers a promising approach to overcome quercetin's bioavailability limitations.