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Updated: Sep 19, 2025
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
Published on: October 6, 2023
Clinical Impact of Multiparametric Contrast-Enhanced Dual-Energy Computed Tomography in Arthritis Imaging: A
Sevtap Tugce Ulas1, Jürgen Mews2, Sarah Ohrndorf3
1Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt - Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.
Objective:
We aimed to evaluate the influence of contrast-enhanced dual-energy computed tomography (CE-DECT) in detecting and differentiating rheumatic joint diseases of the hand.
Methods:
In this prospective study, patients with suspected arthritis of the hand were investigated consecutively alongside the standard clinical procedure. CE-DECT with sequential rotations was performed in all patients before and 3-minutes after weight-adapted contrast agent application. Reconstructions included two-material decomposition for tophus imaging, virtual noncalcium for bone marrow edema, and CT subtraction for soft-tissue inflammation. All postprocessed images and original CT reconstructions were rated by two radiologists in consensus to generate an imaging diagnosis. Imaging findings in CE-DECT were juxtaposed with the initial and final evaluations by referring rheumatologists. This evaluation focused on surrogate performance criteria, emphasizing the added diagnostic value of CE-DECT in detecting specific imaging biomarkers associated with various arthritic pathologies. A subsequent survey assessed CE-DECT's diagnostic utility and impact on patient management, rated on a 1 to 10 scale. Descriptive statistics were employed.
Results:
Overall, 136 patients were included in the analysis. In 119 patients (87.5%), the CE-DECT findings agreed with the final diagnosis. In 67 patients (49.2%), the diagnosis was changed following CE-DECT. Rheumatologists rated CE-DECT's diagnostic utility at a mean ± SD of 8.5 ± 2.1 and its contribution to patient management at 8.4 ± 1.8.
Conclusion:
CE-DECT showed high value for diagnosis and management of patients with suspected inflammatory arthritis. Its diverse diagnostic capabilities suggest that it can develop an important addition to current clinical workup pathways.
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