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Updated: Sep 19, 2025

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells
Published on: December 25, 2021
Bacterial ribosome heterogeneity facilitates rapid response to stress
Yi-Lin Shen1, Lei Xu1, Ying Zhou1
1Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Abstract:
Bacteria live under constant pressure from external signals, necessitating a rapid capacity to reprogram their metabolism. The ribosome, once considered a uniform and static entity, is now recognized for its compositional heterogeneity. Despite its prevalence, the role of this heterogeneity in regulating bacterial translation remains incompletely understood. This review explores how ribosomal heterogeneity may serve as a conserved mechanism for fine-tuning gene expression, enabling swift adjustments to environmental stress. We present recent findings on the regulatory potential of ribosome heterogeneity and its broader implications for bacterial adaptation, pathogenesis, and the development of novel antimicrobial strategies.
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