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Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

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Comparison of MRI and prognostic features of intrahepatic cholangiocarcinoma between patients with and without

Se Jin Choi1, Dong Hwan Kim2, Sang Hyun Choi1

  • 1Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

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Hepatitis B virus (HBV) infection is linked to distinct MRI features in intrahepatic cholangiocarcinoma (ICCA). HBV-positive ICCA patients show a higher intrahepatic recurrence rate after surgery.

Keywords:
CholangiocarcinomaHepatitis BLiver neoplasmsMagnetic resonance imagingPrognosis

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Area of Science:

  • Hepatology
  • Oncology
  • Radiology

Background:

  • Intrahepatic cholangiocarcinoma (ICCA) is a primary liver cancer with varying clinical presentations.
  • Hepatitis B virus (HBV) infection is a known risk factor for liver diseases, including HCC, but its role in ICCA is less defined.

Purpose of the Study:

  • To compare clinical, MRI, and prognostic features of ICCA between patients with and without HBV infection.
  • To investigate the impact of HBV status on recurrence and survival after curative resection for ICCA.

Main Methods:

  • Retrospective analysis of 211 ICCA patients who underwent preoperative MRI and curative-intent surgery.
  • Independent review of MRI features by two radiologists.
  • Comparison of clinicopathologic and MRI characteristics based on HBV status.
  • Assessment of recurrence-free survival (RFS) and overall survival (OS) using Kaplan-Meier and log-rank tests.
  • Logistic regression analysis to identify predictors of intrahepatic recurrence.

Main Results:

  • Of 211 patients, 38.4% were HBV-positive. Mass-forming ICCA and peripheral tumor location were more common in HBV-positive patients.
  • HBV-positive patients showed more frequent rim/non-rim arterial-phase enhancement and radiologically evident cirrhosis on MRI.
  • While RFS and OS did not significantly differ, intrahepatic recurrence rates were higher in the HBV-positive group (37.0% vs. 23.1%).
  • HBV positivity independently predicted higher intrahepatic recurrence (OR, 1.93; P=0.047).

Conclusions:

  • HBV-associated ICCA exhibits distinct MRI features compared to HBV-negative ICCA.
  • HBV positivity is associated with a significantly higher rate of intrahepatic recurrence following curative resection for ICCA.
  • These findings highlight the importance of considering HBV status in the management and prognosis of ICCA.