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Role of GDF-15 and NRG-1 as predictive markers of coronary artery disease

Monika Samra1,2, Indu Arora2, Rajiv Narang3

  • 1Dr. B R Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, 110007, India.

Molecular Biology Reports
|June 3, 2025
PubMed

Insights

The GDF15 rs4808793 polymorphism and elevated GDF15 and NRG1 gene expression are significantly linked to coronary artery disease (CAD). These factors may serve as valuable biomarkers for predicting CAD severity and guiding patient management.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Disease Research

Background:

  • Coronary artery disease (CAD) presents a significant global health burden, with diagnostic challenges persisting.
  • This study investigates the genetic and molecular associations of GDF15 and NRG1 with CAD.

Purpose of the Study:

  • To examine the association between the GDF15 -3148 C/G (rs4808793) polymorphism and CAD.
  • To evaluate GDF15 and NRG1 gene and protein expression levels in CAD patients.
  • To determine the potential of these markers in predicting CAD severity.

Main Methods:

  • Genotyping of GDF15 rs4808793 polymorphism using PCR-RFLP in CAD patients and controls.
  • Quantification of GDF15 and NRG1 mRNA and protein expression via real-time PCR, Western blot, and ELISA.

Main Results:

  • The GDF15 (CG+GG) genotype was significantly associated with CAD (p < 0.0001).
  • Elevated GDF15 and NRG1 mRNA and protein levels were observed in CAD patients compared to controls (p < 0.0001).
  • Receiver Operating Characteristic (ROC) curve analysis indicated strong discriminatory power for both markers, correlating positively with disease severity.

Conclusions:

  • The GDF15 rs4808793 polymorphism is significantly associated with CAD.
  • Elevated GDF15 and NRG1 expression levels are linked to CAD.
  • These findings suggest GDF15 and NRG1 may serve as predictive biomarkers for CAD severity and management.
Abstract

Keywords:
Coronary artery diseaseGrowth differentiation factor 15Neuregulin1Predictive markersRT-PCRSingle nucleotide polymorphism

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