Thoracic Adipose Volume is Associated with Occult Nodal Disease and Disease-Free Survival in Females with Clinically Node-Negative Non-Small Cell Lung Cancer
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Reduced thoracic and epicardial fat in female lung cancer patients is linked to occult nodal disease. This finding may help identify high-risk individuals for better non-small cell lung cancer management.
Area Of Science
- Oncology
- Radiology
- Body Composition Analysis
Background
- Reduced L3 adipose area correlates with poorer survival in non-small cell lung cancer (NSCLC).
- The association between adiposity and occult nodal disease (OND) in clinically node-negative (cN0) NSCLC patients is not well understood.
Purpose Of The Study
- To investigate the relationship between thoracic adiposity indices and the presence of OND in cN0 NSCLC patients.
- To determine if body composition analysis can predict OND in this patient cohort.
Main Methods
- Retrospective analysis of 224 NSCLC patients who underwent resection and nodal staging (2010-2021).
- Volumetric body composition analysis of preoperative CT scans (T1-T12) to assess adiposity indices.
- Logistic regression models were used to analyze associations between adiposity and OND.
Main Results
- Occult nodal disease (pN+) was identified in 26% of patients.
- In female patients, lower thoracic subcutaneous adipose index and epicardial adipose index were significantly associated with OND.
- Multivariable analysis confirmed the association of reduced thoracic subcutaneous adipose index (OR 6.32) and epicardial adipose index (OR 2.96) with OND in females.
Conclusions
- Reduced thoracic subcutaneous and epicardial adipose volume are independently associated with occult nodal disease in female NSCLC patients.
- Body composition analysis may serve as a valuable tool for risk stratification in cN0 NSCLC patients.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...