Determination of Folic Acid in Various Dietary Supplement Dosage Forms by UPLC/PDA: Single-Laboratory Validation, First Action 2024.09
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View abstract on PubMed
Summary
This summary is machine-generated.The Expert Review Panel approved a revised method for quantifying folic acid in dietary supplements. This validated UPLC/PDA method, now meeting performance requirements, is recommended for official final action status.
Area Of Science
- Analytical Chemistry
- Food Science
- Dietary Supplements
Background
- A validated method for folic acid quantification in diverse dietary supplements was previously approved by the AOAC Expert Review Panel (ERP) with First Action Official Method status.
- The method covers various dosage forms including tablets, capsules, powder drinks, softgels, and gummies.
Purpose Of The Study
- To address the ERP's request, a recovery test for gummy samples was reperformed using a revised procedure.
- To refine and clarify the existing method based on single-laboratory validation parameters.
Main Methods
- Determination of Folic Acid in Various Dietary Supplement Dosage Forms using Ultra-Performance Liquid Chromatography with Photodiode Array detection (UPLC/PDA).
Main Results
- The revised recovery test for gummies achieved a range of 94.6-106.5% when spiked at 20%, 50%, and 80% levels.
- Method clarifications and minor typographical errors were addressed in the revised procedure.
Conclusions
- The Expert Review Panel (ERP) adopted the revised method after analysis and discussion of the report and results.
- The updated method meets the Standard Method Performance Requirement (SMPR®) 2022.002 and is recommended for Final Action status.
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