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Updated: Jan 18, 2026
An “All-laser” Endothelial Transplant
Published on: July 6, 2015
Spontaneous Artificial Corneal Endothelial Graft Reattachment: Case Report
Mechleb Nicole1,2, Gatinel Damien1,2, Saad Alain1,2
1Department of Ophthalmology, Rothschild Foundation Hospital, Paris, France ; and.
Purpose:
EndoArt, a synthetic endothelial substitute for corneal edema, often requires multiple rebubbling procedures because of high detachment rates. This study reports 2 cases of spontaneous EndoArt reattachment, suggesting a potential alternative management approach.
Methods:
Two patients with endothelial dysfunction underwent EndoArt implantation. Both experienced partial detachment postoperatively. Although rebubbling was considered, a conservative approach was taken, leading to spontaneous reattachment. Serial anterior segment optical coherence tomography (AS-OCT) monitored graft adherence and corneal thickness.
Results:
Spontaneous reattachment occurred within 2 to 6 weeks, accompanied by progressive corneal thinning and clarity improvement. No further intervention was required, and reattachment remained stable for 6 to 8 months. These cases challenge the notion that all EndoArt detachments necessitate immediate rebubbling.
Conclusions:
This is the first report of spontaneous EndoArt reattachment. Although rebubbling remains standard practice, observation may be a viable option in select cases, reducing the need for additional procedures. Further studies are needed to refine management strategies and improve outcomes.
