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Polymorphonuclear dysfunction in bronchopulmonary diseases in human adults
Abstract:
Polymorphonuclear (PMN) functions were assessed in 55 patients with asthma or bronchial bacterial infection to evaluate the systemic phagocyte capability of patients with bronchopulmonary diseases. Random migration, nitroblue tetrazolium dye reduction, and Candida killing activity were markedly decreased in the 2 types of patients studied. PMN dysfunction was more pronounced in the most affected and heavily treated patients. Considering both the rare occurrence of congenital polymorphonuclear defects and the age of the patients studied we concluded that the PMN abnormalities observed were secondary to the onset of respiratory disease. This impairment of circulating phagocytes may contribute to the rise of a systemic susceptibility to infection able to aggravate the underlying bronchopulmonary disease.
Insights
Polymorphonuclear (PMN) functions are impaired in patients with asthma or bacterial lung infections. This dysfunction in circulating phagocytes may increase susceptibility to infections, worsening respiratory disease.
Area of Science:
- Immunology
- Pulmonology
- Infectious Diseases
Background:
- Bronchopulmonary diseases like asthma and bacterial infections can impact immune function.
- Systemic phagocyte capability is crucial for combating infections.
Purpose of the Study:
- To evaluate the systemic phagocyte capability in patients with asthma or bronchial bacterial infections.
- To determine if polymorphonuclear (PMN) functions are compromised in these patients.
Main Methods:
- Assessed PMN functions in 55 patients with asthma or bronchial bacterial infection.
- Measured random migration, nitroblue tetrazolium dye reduction, and Candida killing activity.
Main Results:
- Markedly decreased PMN functions were observed in both patient groups.
- PMN dysfunction was more pronounced in severely affected and heavily treated patients.
- Abnormalities were deemed secondary to respiratory disease, not congenital defects.
Conclusions:
- Impaired PMN function in respiratory diseases suggests reduced systemic phagocyte capability.
- This phagocyte impairment may lead to increased susceptibility to infections.
- Aggravation of underlying bronchopulmonary disease can result from this heightened infection susceptibility.