Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphonuclear dysfunction in bronchopulmonary diseases in human adults.

P Laharrague, J Corberand, G Fillola

    Journal of Clinical & Laboratory Immunology
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016
    Same author

    Immuno-metabolism and adipose tissue: The key role of hematopoietic stem cells.

    Biochimie·2015
    Same author

    [Home telemonitoring of lung-transplanted patients: A feasibility study].

    Revue des maladies respiratoires·2014
    Same author

    [Evaluation of a manual CPAP home telemonitoring device to an automatic one].

    Revue des maladies respiratoires·2014
    Same author

    [Telemedicine and lung transplanted patients: A feasibility study].

    Revue des maladies respiratoires·2014
    Same author

    [Impact of facial versus nose mask on the length of use of CPAP in patients with Sleep Apnea Syndrome?].

    Revue des maladies respiratoires·2013

    Polymorphonuclear (PMN) functions are impaired in patients with asthma or bacterial lung infections. This dysfunction in circulating phagocytes may increase susceptibility to infections, worsening respiratory disease.

    Area of Science:

    • Immunology
    • Pulmonology
    • Infectious Diseases

    Background:

    • Bronchopulmonary diseases like asthma and bacterial infections can impact immune function.
    • Systemic phagocyte capability is crucial for combating infections.

    Purpose of the Study:

    • To evaluate the systemic phagocyte capability in patients with asthma or bronchial bacterial infections.
    • To determine if polymorphonuclear (PMN) functions are compromised in these patients.

    Main Methods:

    • Assessed PMN functions in 55 patients with asthma or bronchial bacterial infection.
    • Measured random migration, nitroblue tetrazolium dye reduction, and Candida killing activity.

    Main Results:

    • Markedly decreased PMN functions were observed in both patient groups.

    Related Experiment Videos

  • PMN dysfunction was more pronounced in severely affected and heavily treated patients.
  • Abnormalities were deemed secondary to respiratory disease, not congenital defects.

    • Conclusions:

    • Impaired PMN function in respiratory diseases suggests reduced systemic phagocyte capability.
    • This phagocyte impairment may lead to increased susceptibility to infections.
    • Aggravation of underlying bronchopulmonary disease can result from this heightened infection susceptibility.