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Perceptions of high-sensitivity C-reactive protein testing (hsCRP) in atherosclerotic cardiovascular disease: a US

Lei Lv1, Ty J Gluckman2, Matthew Strum1

  • 1Novo Nordisk Inc., Plainsboro, NJ, USA.

Future Cardiology
|June 3, 2025
PubMed

Insights

Clinician surveys reveal limited evidence of improved cardiovascular outcomes hinders high-sensitivity C-reactive protein (hsCRP) testing for systemic inflammation (SI) in atherosclerotic cardiovascular disease (ASCVD) management.

Area of Science:

  • Cardiology
  • Clinical Pathology
  • Preventive Medicine

Background:

  • High-sensitivity C-reactive protein (hsCRP) is a biomarker for systemic inflammation (SI).
  • Elevated hsCRP is a risk-enhancing factor for cardiovascular disease in primary prevention.
  • Understanding clinician perspectives on hsCRP testing in atherosclerotic cardiovascular disease (ASCVD) and chronic kidney disease (CKD) is crucial.

Purpose of the Study:

  • To investigate US clinicians' opinions on using hsCRP testing in managing ASCVD patients.
  • To identify drivers and barriers influencing hsCRP testing adoption.
  • To assess post-hsCRP testing actions and their impact on clinical decision-making.

Main Methods:

  • Survey of clinicians who ordered hsCRP testing with patient data evaluation.
  • Data collected between June 2023 and August 2023.
  • Endpoints included perceived drivers, barriers, and post-test actions related to SI recognition.

Main Results:

  • Lack of evidence for improved cardiovascular outcomes (50%) and unproven efficacy (33%) were key barriers to hsCRP testing.
  • Cost, insurance, and patient refusal also presented challenges.
  • Clinicians often believed SI management wouldn't alter ASCVD treatment decisions.

Conclusions:

  • Perceived insufficient evidence linking hsCRP testing to improved cardiovascular outcomes limits its use in ASCVD patients.
  • Further research is needed to demonstrate the clinical utility of hsCRP in improving patient outcomes.
  • Addressing clinician concerns regarding evidence and efficacy is essential for wider hsCRP adoption.
Abstract

Keywords:
C-reactive proteinLDLatherosclerosischolesterolchronicinflammationrenal insufficiency

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