Related Experiment Video

Updated: Jul 16, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K

Cardiac magnetic resonance imaging to predict left ventricular reverse remodelling in non-ischaemic dilated

B S Berdibekov1, S A Alexandrova1, N I Bulaeva1

  • 1A.N. Bakulev National Medical Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.

Clinical Radiology
|June 3, 2025
PubMed

Insights

Absence of late gadolinium enhancement (LGE) on cardiac MRI predicts left ventricular reverse remodelling in non-ischaemic dilated cardiomyopathy. Lower LGE, T1, and ECV indicate myocardial recovery, guiding treatment decisions.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Non-ischaemic dilated cardiomyopathy (DCM) is a significant cause of heart failure.
  • Left ventricular reverse remodelling (LVRR) is associated with improved outcomes in DCM patients.
  • Predictive markers for LVRR are crucial for optimizing patient management.

Purpose of the Study:

  • To systematically review and meta-analyze the predictive value of cardiac magnetic resonance (CMR) imaging parameters for LVRR in non-ischaemic DCM.
  • To assess the role of late gadolinium enhancement (LGE), native T1, and extracellular volume (ECV) in predicting LVRR.

Main Methods:

  • Systematic search of electronic databases for relevant studies.
  • Random-effect meta-analysis of data from 17 studies involving 1,465 participants.
  • Assessment of heterogeneity using the I² statistic.

Main Results:

  • Late gadolinium enhancement (LGE) was a strong univariate predictor of LVRR (OR: 3.65).
  • LGE remained predictive after adjusting for baseline characteristics (adjusted OR: 2.84).
  • Patients without LVRR showed greater LGE extent, longer native T1 times, and higher ECV.

Conclusions:

  • Absence of LGE is a robust predictor of LVRR in non-ischaemic DCM.
  • CMR parameters (LGE, T1, ECV) are valuable indicators of myocardial recovery.
  • Incorporating CMR findings into clinical algorithms can enhance DCM management and outcomes.
Abstract

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.6K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.2K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...