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Updated: Sep 19, 2025

Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling
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Published on: August 19, 2017

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Effect of histone deacetylases on pancreatic physiology and pathology: a review

Xinran Song1, Xiaofeng Wu2, Jun Yang3

  • 1Capital Medical University, Beijing 100069, China.

International Journal of Biological Macromolecules
|June 3, 2025
PubMed

Insights

Pancreatic diseases are rising globally. Targeting histone deacetylases (HDACs) offers new therapeutic strategies for pancreatic diseases, including combination therapies.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Gastroenterology

Background:

  • Pancreatic diseases incidence is increasing worldwide, necessitating novel therapeutic targets.
  • Histone deacetylases (HDACs) play crucial roles in pancreatic physiology and disease.
  • Epigenetic regulation by HDACs impacts various vital activities within the pancreas.

Purpose of the Study:

  • To review the multifaceted roles of HDACs in distinct pancreatic cell types.
  • To explore the therapeutic potential of targeting HDACs for pancreatic diseases.
  • To discuss HDAC inhibitors as a potential combination therapy strategy.

Main Methods:

  • Literature review of HDAC functions in pancreatic cells.
  • Analysis of therapeutic strategies targeting HDACs.
  • Evaluation of HDAC inhibitors in combination therapy contexts.

Main Results:

  • HDACs are implicated in diverse physiological and pathological processes in the pancreas.
  • Targeting HDACs presents a promising avenue for novel pancreatic disease treatments.
  • HDAC inhibitors show potential for synergistic effects in combination therapies.

Conclusions:

  • Understanding HDAC roles is key to developing advanced pancreatic disease treatments.
  • Targeting HDACs offers new therapeutic and diagnostic possibilities.
  • Combination therapies involving HDAC inhibitors may improve patient outcomes.
Keywords:
Cell biologyHistone deacetylasesInsightsPancreasPancreatic cancer

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