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Definitions of early COPD and markers and tools for predicting progression: a systematic review protocol

  • 0University of Cambridge School of Clinical Medicine, Cambridge, UK alastair.watson7@nhs.net.
Bmj Open +

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June 3, 2025

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June 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This review examines early Chronic Obstructive Pulmonary Disease (COPD) definitions and progression markers. It aims to standardize terminology and identify predictive tools for better early COPD diagnosis and management.

Area Of Science

  • Pulmonary Medicine
  • Respiratory Research
  • Clinical Epidemiology

Background

  • Chronic Obstructive Pulmonary Disease (COPD) is a major global health burden.
  • Early diagnosis and intervention are critical for managing COPD progression.
  • A lack of standardized definitions for early COPD hinders research and clinical practice.

Purpose Of The Study

  • To systematically review current research on early COPD definitions and terminology.
  • To identify and evaluate markers and tools for predicting early COPD progression.
  • To inform consensus on definitions and guide future research for novel management strategies.

Main Methods

  • Comprehensive literature search across multiple databases (CENTRAL, MEDLINE, PubMed, Scopus, Web of Science, Google Scholar).
  • Systematic review of clinical studies focusing on early COPD definitions and progression predictors.
  • Quality assessment using modified Downs and Black checklist and RoB 2 tool.

Main Results

  • Analysis of terms and definitions used in current early COPD literature (Stage 1).
  • Identification of proposed markers and tools for predicting early COPD progression (Stage 2).
  • Evaluation of the quality of evidence for identified markers and tools.

Conclusions

  • Consensus on early COPD definitions is needed to advance clinical utility and research.
  • Validated markers and tools are essential for predicting disease progression and developing targeted interventions.
  • This review will provide a foundation for future research and improved management of early COPD.

Keywords:

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