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CCR2+ monocytes promote memory CD8+ T-cell differentiation via membrane-bound TGF-β
Lina Sun1,2,3,4, Cangang Zhang1,2, Anjun Jiao1,2,3,4
1Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Cellular & Molecular Immunology
|June 3, 2025
Summary
Monocytes promote memory CD8+ T cell differentiation by interacting with CD8+ memory precursor cells. This interaction, dependent on transforming growth factor-beta (TGF-β), is crucial for CD8+ T cell development during infection.
Area of Science:
- Immunology
- Cell Biology
- Systems Biology
Background:
- CD8+ T cells differentiate into effector and memory cells upon antigen recognition.
- The spatial factors influencing CD8+ T cell fate during acute infection remain unclear.
Purpose of the Study:
- To investigate the spatial determinants governing effector and memory CD8+ T cell differentiation.
- To elucidate the role of monocytes in CD8+ T cell fate decisions.
Main Methods:
- Integration of single-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics.
- Analysis of cell-cell interactions and molecular signaling pathways.
Main Results:
- Naïve CD8+ T cells differentiate into memory precursor (MP) cells and IFN-responsive cells.
- Monocytes, particularly the Ly6ChiCCR2+ subset, colocalize with CD8+ MP cells.
- Monocytes promote memory CD8+ T cell differentiation via cell-cell contact and TGF-β signaling.
Conclusions:
- Monocytes play a critical role in CD8+ T cell memory development.
- A novel spatial mechanism involving monocyte-derived TGF-β drives memory CD8+ T cell differentiation.
- Understanding these interactions is key to developing strategies for enhancing T cell memory.
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