Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene-Environment Interactions

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

Background and Environment Affect Phenotype

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...

Causes of Social Behavior III: Biological and Environmental Influences

Causes of Social Behavior III: Biological and Environmental Influences

Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Peripubertal Changes in Asthma.

American journal of respiratory and critical care medicine·2026

Same author

Genetic variants underpinning lung function decline in the Lifelines general population cohort study.

ERJ open research·2026

Same author

Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals.

Allergy·2026

Same author

DNA Methylation at Birth Showing Age-Specific Association with Atopy in Children: A Prospective Longitudinal Study.

Epigenomes·2026

Same author

Epigenome-Wide DNA Methylation Levels During Pregnancy: Associations with Parity Across Diverse Populations.

Epigenomes·2026

Same author

Impact of SARS-CoV-2 infection on subclinical myocardial injury in the general population: the Trøndelag Health Study.

European journal of preventive cardiology·2026

Search research articles

Related Experiment Video

Updated: Sep 19, 2025

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.

Marie Standl^1,2, Ashley Budu-Aggrey³, Luke J Johnston⁴

¹Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

|June 4, 2025

Summary

Early-life dog exposure may modify genetic risk for atopic eczema (AE). Gene-environment interaction analysis suggests a protective effect of dog ownership, potentially via IL7R, warranting further investigation into AE pathogenesis.

Keywords:

atopic eczema dog environment gene interaction

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Related Experiment Videos

Last Updated: Sep 19, 2025

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

Genetics
Environmental Health
Dermatology

Background:

Atopic eczema (AE) pathogenesis involves multiple genetic and environmental factors.
Understanding gene-environment interactions (G×E) is crucial for elucidating AE pathophysiology.

Purpose of the Study:

To investigate gene-environment interactions in atopic eczema.
To identify specific environmental factors and genetic variants that interact in AE development.

Main Methods:

Analysis of data from 16 European studies on 24 AE-associated loci and 18 early-life environmental factors.
Replication analysis using 10 additional studies and in vitro modeling to assess gene-environment interactions.

Main Results:

Suggestive evidence for 14 interactions between AE risk variants and environmental factors (e.g., antibiotic use, pet ownership, breastfeeding).
Replicated interaction between dog exposure and rs10214237 (near IL7R) on chromosome 5p13.2, showing a protective effect of dog exposure.
In vitro modeling indicated rs10214237 genotype influences IL-7R expression and response to dog exposure.

Conclusions:

Preliminary evidence suggests early-life dog exposure modifies the genetic effect of rs10214237 on AE risk via IL7R.
Findings support observational data on the protective effect of dog ownership in AE.
Other investigated G×E interactions likely have weak effects.