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Updated: Sep 19, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
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Antimicrobial resistance: Current challenges and future directions

Bipin Puri1, Raju Vaishya2, Abhishek Vaish3

  • 1Director Medical Services, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India.

Medical Journal, Armed Forces India
|June 4, 2025
PubMed
Abstract

Insights

Antimicrobial resistance (AMR) and superbugs threaten critical care patients. Combating this requires antibiotic stewardship, new therapies, infection control, and global collaboration to ensure effective treatments.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Pharmacology

Background:

  • Antibiotic misuse drives antimicrobial resistance (AMR), a major threat in critical care.
  • Superbugs are rendering conventional treatments ineffective for critically ill patients.

Purpose of the Study:

  • To review the challenges posed by superbugs and AMR in critical care settings.
  • To highlight potential solutions and strategies for combating AMR.

Main Methods:

  • A narrative review approach was employed.
  • Searches were conducted in PubMed, Scopus, and Google Scholar using keywords such as "antimicrobial resistance" and "superbugs".

Main Results:

  • Antibiotic overuse and misprescription fuel superbug development, increasing costs and hospital stays.
  • Effective AMR combat requires a multifaceted strategy: antibiotic stewardship, novel therapies, infection control, public education, and stakeholder collaboration.
  • Research gaps exist in understanding environmental AMR influences; future directions include new antibiotics, diagnostics, and drug combinations.

Conclusions:

  • AMR is a significant threat to critical care interventions.
  • A multifaceted approach is essential to preserve the efficacy of critical care treatments.
  • Addressing AMR challenges ensures effective patient care for the critically ill.
Keywords:
Antibacterial agentsCritical careDrug resistanceGlobal healthHumans

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