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Single high-dose amphotericin B for cryptococcal meningitis: First Indian experience.
Rohit Vashisht1, Sumit Arora2, Abhinav Kumar3
1Associate Professor, Department of Internal Medicine, Armed Forces Medical College, Pune, India.
Medical Journal, Armed Forces India
|June 4, 2025
Summary
A new, cost-effective liposomal amphotericin B regimen is recommended for cryptococcal meningitis in people living with HIV. This Indian experience highlights its use in two patients managed at military immunodeficiency centers.
Area of Science:
- Infectious Diseases
- HIV/AIDS Management
- Pharmacology
Background:
- Cryptococcus is a significant cause of central nervous system disease in people living with HIV (PLHIV).
- Conventional Amphotericin B treatment regimens are often costly and associated with toxicity.
- The World Health Organization (WHO) recommends a cost-effective, single high-dose liposomal amphotericin B regimen.
Observation:
- This study presents the Indian experience with the WHO-recommended liposomal amphotericin B regimen.
- Two patients with cryptococcal meningitis managed at Armed Forces immunodeficiency centers were treated with this regimen.
Findings:
- The study details the clinical outcomes and management of these two cases.
- This highlights the practical application of the new regimen in an Indian military healthcare setting.
Implications:
- The findings suggest liposomal amphotericin B as a viable, cost-effective option for cryptococcal meningitis in PLHIV in India.
- This approach may improve treatment accessibility and patient outcomes in resource-limited settings.
- Further studies are warranted to evaluate the efficacy and safety in a larger cohort.
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