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Related Experiment Video

Updated: May 14, 2026

Isolation, Processing and Analysis of Murine Gingival Cells
09:47

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Published on: July 2, 2013

AIM2-Driven Inflammation in Periodontitis: Mechanisms and Systemic Implications.

Zhen Fan1, Rui Chen1, Xiaomei Xie1

  • 1Affliated Hainan Hospital of Hainan Medical University (Hainan General Hospital), Haikou, 570100, People's Republic of China.

Journal of Inflammation Research
|June 4, 2025
PubMed
Summary

AIM2 inflammasome drives periodontitis inflammation and may link it to cardiovascular disease through DNA repair. Targeting AIM2 offers a dual therapy for periodontal and systemic health.

Keywords:
AIM2DNA repairinflammasomeperiodontitissystemic diseases

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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Area of Science:

  • Inflammasome biology
  • Periodontal disease research
  • Systemic disease mechanisms

Background:

  • Periodontitis is a chronic inflammatory condition linked to systemic diseases like diabetes and cardiovascular disease.
  • The inflammasome, particularly AIM2 (Absent in Melanoma 2), plays a crucial role in inflammation.
  • Understanding AIM2's role in periodontitis is vital for exploring its connection to systemic health.

Purpose of the Study:

  • To investigate the role of AIM2 in periodontitis pathogenesis.
  • To explore AIM2's involvement in local inflammation and DNA repair within periodontal tissues.
  • To analyze the association between AIM2 expression and systemic diseases, particularly cardiovascular disease.

Main Methods:

  • AIM2 expression analysis in saliva and gingival crevicular fluid (GCF) from periodontitis patients.
  • Utilized a mouse periodontitis model and in vitro gingival fibroblast experiments.
  • Employed Gene Set Enrichment Analysis (GSEA) and Protein-Protein Interaction (PPI) network analysis for systemic disease associations.

Main Results:

  • AIM2 was significantly upregulated in periodontitis patients and models, correlating with key inflammatory markers (IL-1β, ASC, Caspase-1).
  • AIM2 localized to the nucleus and co-localized with inflammatory markers in periodontal tissues.
  • GSEA linked high AIM2 expression to cardiovascular diseases; its suppression conferred protection. PPI analysis revealed interactions with DNA repair proteins (THOC2, SETX, ATM).

Conclusions:

  • AIM2 drives local inflammation in periodontitis and potentially links it to systemic diseases via DNA repair and inflammation.
  • AIM2 emerges as a potential therapeutic target for managing periodontitis and associated systemic risks.
  • Targeting AIM2 presents a dual therapeutic strategy for controlling periodontal inflammation and mitigating systemic disease risks like cardiovascular disorders.