Enhanced Acetaminophen Detection in Dolo-650 Tablets Using Electrocatalyst SnWO₄-DNA Composite and Its Antibacterial...

Area of Science:

• Electrochemistry
• Materials Science
• Nanotechnology

Background:

• Acetaminophen (AMP) is a widely used analgesic, necessitating sensitive detection methods.
• Developing multifunctional materials for simultaneous chemical sensing and antimicrobial applications is of significant interest.

Purpose of the Study:

• To develop a highly sensitive electrochemical sensor for acetaminophen detection in pharmaceutical formulations.
• To investigate the antibacterial properties of the developed sensing material.
• To explore the potential of the SnWO4-DNA composite as a dual-use material in medical diagnostics.

Main Methods:

• Fabrication of a SnWO4-DNA composite as the sensing material.
• Characterization using Brunauer-Emmett-Teller (BET) for surface area, Transmission Electron Microscopy (TEM) for DNA presence, and X-ray photoelectron spectroscopy (XPS) for chemical composition.
• Electrochemical measurements for acetaminophen detection and antibacterial assays against Klebsiella pneumoniae and Staphylococcus aureus.

Main Results:

• The SnWO4-DNA sensor demonstrated high sensitivity for acetaminophen detection with a wide linear range (200 nM-1 mM) and a low limit of detection (55 nM).
• The sensor exhibited excellent reversibility and fast detection capabilities, suitable for real-time monitoring.
• The composite effectively inhibited the growth of Klebsiella pneumoniae and Staphylococcus aureus, indicating significant antibacterial activity.

Conclusions:

• The developed SnWO4-DNA electrochemical sensor is highly effective for sensitive acetaminophen detection.
• The material possesses dual functionality, offering both chemical sensing and potent antibacterial properties.
• This innovative composite holds promise for applications in medical diagnostics, pathogen control, and personalized medicine.