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Primary Cutaneous SMARCA4-Deficient Tumor With Metastases
Supriya Pradhan1, Martha Lehman2, Abdul Mohd Tahir3
1Departments of Anatomical Pathology, New South Wales Health Pathology, Coffs Harbour, Australia.
Abstract:
SMARCA-4 deficient cutaneous tumor is extremely uncommon. These are aggressive tumors to begin with, and should be recognised at the outset from their extremely high-grade morphology and absence or extreme paucity of not only usual carcinoma markers but also complete absence of SMARCA-4, which should be performed. We present such a case with extensive metastases, notable for relatively quite small size of primary skin lesion. The case must be evaluated in full to rule out systemic including thoraco-visceral disease.
Insights
SMARCA-4 deficient cutaneous tumors are rare and aggressive. Early recognition of their high-grade morphology and lack of SMARCA-4 protein is crucial for diagnosis and treatment.
Area of Science:
- Oncology
- Dermatopathology
Background:
- SMARCA-4 deficient cutaneous tumors are exceptionally rare.
- These aggressive neoplasms present with high-grade morphology.
