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Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...

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Related Experiment Video

Updated: Jun 11, 2026

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth
02:33

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Published on: May 17, 2024

In Vitro Evaluation of Bovine Pulp Dissolution Using Dual Rinse HEDP at Different Temperatures.

Dina Abdellatif1, Gianluca Plotino2, Edouard Euvrard1

  • 1Department of Maxillo-facial Surgery and Stomatology, CHU Besançon, Besançon, France; Sinergies Laboratory EA 4662, University of Franche-Comté, Besançon, France.

European Endodontic Journal
|June 4, 2025
PubMed
Summary
This summary is machine-generated.

Elevated temperatures significantly enhance pulp tissue dissolution by sodium hypochlorite (NaOCl) and Dual Rinse HEDP. Heating irrigants to 80°C drastically reduces dissolution time compared to body temperature.

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14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Area of Science:

  • Endodontics
  • Dental Materials Science

Background:

  • Sodium hypochlorite (NaOCl) is a widely used irrigant in endodontics for pulp tissue dissolution.
  • Optimizing irrigant efficacy is crucial for successful root canal treatment.
  • Dual Rinse HEDP is a novel irrigant with potential applications in endodontic procedures.

Purpose of the Study:

  • To evaluate the pulp tissue dissolution efficacy of Dual Rinse HEDP at varying temperatures.
  • To compare the performance of Dual Rinse HEDP with sodium hypochlorite (NaOCl) under different temperature conditions.

Main Methods:

  • Standardized pulp tissue samples were exposed to NaOCl (5.25%) and Dual Rinse HEDP at body temperature (36.8°C) and elevated temperature (80°C).
  • Dissolution times were recorded using digital microscopy and stopwatch.
  • Statistical analysis included one-way ANOVA and Tukey's HSD post hoc test (p<0.05).

Main Results:

  • Both NaOCl and Dual Rinse HEDP at 80°C demonstrated significantly faster pulp tissue dissolution compared to body temperature (p<0.05).
  • No significant difference in dissolution time was observed between NaOCl and Dual Rinse HEDP at 80°C (p>0.05).
  • Groups treated at body temperature showed prolonged dissolution times, with no significant difference between NaOCl and Dual Rinse HEDP (p>0.05).

Conclusions:

  • Temperature plays a critical role in the pulp dissolution efficacy of both NaOCl and Dual Rinse HEDP.
  • Dual Rinse HEDP shows potential for use in combination with NaOCl for enhanced chelation during endodontic treatment.