Evaluation of surgical modalities for stage 0 to stage II acral lentiginous melanoma: a National Cancer Database study
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View abstract on PubMed
Summary
This summary is machine-generated.Biopsy followed by gross excision (BFGE) shows improved survival outcomes for acral lentiginous melanoma (ALM) compared to wide local excision (WLE). Further investigation into BFGE for ALM is warranted.
Area Of Science
- Oncology
- Surgical Oncology
- Dermatology
Background
- Acral lentiginous melanoma (ALM) has higher recurrence rates than other melanoma subtypes.
- Wide local excision (WLE) is the standard surgical treatment for ALM, but research on alternative surgical modalities is limited.
Purpose Of The Study
- To evaluate and compare overall survival outcomes for different surgical treatments in patients with stage 0-II acral lentiginous melanoma.
Main Methods
- Retrospective cohort study using the National Cancer Database (2004-2021).
- Included patients with histologically confirmed ALM (stage 0-II).
- Statistical analyses included Chi-squared tests, Kaplan-Meier curves, and Cox proportional hazards regression.
Main Results
- Biopsy followed by gross excision (BFGE) demonstrated significantly greater overall survival than WLE (median 204.8 months vs. 181.6 months).
- BFGE also showed a lower rate of residual tumor at the primary site (92.1% clear margins).
- WLE was frequently performed on lesions with Breslow depth between 0.1-5 mm and larger than 3 cm.
Conclusions
- Surgical modality significantly impacts overall survival in ALM patients.
- BFGE presents a promising alternative or adjunct to WLE and warrants further investigation for ALM treatment.
- Different surgical approaches may be optimal depending on tumor characteristics.
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