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Updated: Jun 14, 2025

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
Sustainable Synthesis of 3-Acylmethylated Coumarins via Photoredox Catalytic Radical Addition/Cyclization in Aqueous
Binfeng Zhu1, Devendar Ponnam1, Mingzhu Li1
1Yunnan Key Laboratory of Chiral Functional Substance Research and Application, Yunnan Minzu University, Yuehua Street, Kunming 650504, China.
Abstract:
A photoredox catalytic cascade radical reaction for the addition/cyclization of arylalkynoates with α-bromoketones in water at room temperature has been developed, offering a green and efficient approach for synthesizing 3-acylmethylated coumarins. This method eliminates the need for conventional organic solvents, phase-transfer catalysts, and excess oxidants, ensuring operational simplicity and environmental sustainability. The reaction is scalable, accommodates a broad array of substrates with outstanding tolerance for functional groups, and offers a versatile route to biologically valuable coumarins.
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