Need for Speed: Topical Roflumilast for Rapid Control of Seborrheic Dermatitis Flares

Seborrheic dermatitis is a common chronic inflammatory skin condition historically treated with topical antifungals and anti-inflammatory agents. While topical corticosteroids are frequently used to quickly control severe disease or flare-ups, efficacy is limited. Topical roflumilast 0.3% foam is the most recent treatment for seborrheic dermatitis approved by the US Food and Drug Administration (FDA); however, its speed of action in controlling flares has not been fully explored. Herein, a case of severe seborrheic dermatitis with significant treatment response to topical roflumilast 0.3% cream, within 24 hours, is described, and the literature reviewed. This case suggests that topical roflumilast may work even faster than topical corticosteroids in controlling flares, and further investigation is warranted to thoroughly assess roflumilast's onset of action and leverage its clinical potential. Citation: Menta N, Vidal SI, Friedman A. Need for speed: topical roflumilast for rapid control of seborrheic dermatitis flares. J Drugs Dermatol. 2025;24(6):634-635. doi:10.36849/JDD.8619.